Hexapeptide growth hormone secretagogue and ghrelin receptor agonist. Studied for its role in GH release mechanisms and ghrelin pathway activity in research models.
GHRP-6 is a research compound available through our china peptide catalog as a finished, lyophilized vial from an established Chinese manufacturer. It belongs to the Synthetic hexapeptide (growth hormone secretagogue)
Research Areas
GH axis pharmacology, ghrelin receptor agonism, appetite signaling, pituitary function
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| GHRP-6 | 5 mg | 10 vials | ≥98% | In Stock |
| GHRP-6 | 10 mg | 10 vials | ≥98% | Out of Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS ([“LC-MS”,“HPLC”,“Water Content”]) . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Available documentation: .
**Where provided, these documents reflect the manufacturer’s batch testing for this compound.
Research Areas
GH Secretagogue and Pituitary Research GHRP-6 is a reference compound in GH axis research, reliably stimulating pulsatile GH release in rodent models via GHS-R1a in anterior pituitary somatotrophs. Studies have examined GH pulse amplitude, duration, and frequency following GHRP-6 administration, as well as synergistic interactions with GHRH analogues (such as CJC-1295). It is commonly used as a pharmacological tool to distinguish GHS-R1a-mediated GH release from GHRH-receptor-mediated mechanisms. Ghrelin Receptor Pharmacology As a high-potency GHS-R1a agonist, GHRP-6 is used to study ghrelin receptor biology including signal transduction, receptor desensitization, and downstream Gq/11 and β-arrestin pathway engagement. Its structural characteristics — particularly D-amino acid substitutions — make it a useful probe for identifying receptor binding requirements and designing improved GHS-R1a ligands. Orexigenic Signaling Research GHRP-6 produces measurable appetite-stimulating effects in preclinical models, mimicking one of ghrelin’s primary biological roles. Research has examined hypothalamic NPY/AgRP pathway activation following GHS-R1a engagement, providing a pharmacological tool for studying the intersection of GH secretion and energy intake regulation — two functions co-regulated by the endogenous ghrelin system. ## Sourcing GHRP-6 From China
GHRP-6 is available through our platform as a china peptide sourced directly from an established Chinese manufacturer. Three points define how we handle it:
- Factory-direct, not trader-sourced. We confirm availability and specification with the manufacturer before the order is confirmed. There is no intermediary resale of unknown-origin vials in this catalog.
- Specification before shipment. The purity and concentration specification shown on this page is the manufacturer’s batch specification. Product-specific quality-control information travels with the order.
- Research-use discipline. Like every listing in our catalog, GHRP-6 is supplied for laboratory research use only, under strict research-use terms.
For buyers comparing chinese peptides suppliers, the practical test is whether the seller can name the manufacturer and show the batch documentation. We work the other way around: the manufacturer and the documentation are the offer. Browse the full catalog or see how sourcing works.
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| GHRP-6 | 5 mg | 10 vials | ≥98% | In Stock |
| GHRP-6 | 10 mg | 10 vials | ≥98% | Out of Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS ([“LC-MS”,“HPLC”,“Water Content”]) . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Available documentation: .
**Where provided, these documents reflect the manufacturer’s batch testing for this compound.
Research Areas
GH Secretagogue and Pituitary Research GHRP-6 is a reference compound in GH axis research, reliably stimulating pulsatile GH release in rodent models via GHS-R1a in anterior pituitary somatotrophs. Studies have examined GH pulse amplitude, duration, and frequency following GHRP-6 administration, as well as synergistic interactions with GHRH analogues (such as CJC-1295). It is commonly used as a pharmacological tool to distinguish GHS-R1a-mediated GH release from GHRH-receptor-mediated mechanisms. Ghrelin Receptor Pharmacology As a high-potency GHS-R1a agonist, GHRP-6 is used to study ghrelin receptor biology including signal transduction, receptor desensitization, and downstream Gq/11 and β-arrestin pathway engagement. Its structural characteristics — particularly D-amino acid substitutions — make it a useful probe for identifying receptor binding requirements and designing improved GHS-R1a ligands. Orexigenic Signaling Research GHRP-6 produces measurable appetite-stimulating effects in preclinical models, mimicking one of ghrelin’s primary biological roles. Research has examined hypothalamic NPY/AgRP pathway activation following GHS-R1a engagement, providing a pharmacological tool for studying the intersection of GH secretion and energy intake regulation — two functions co-regulated by the endogenous ghrelin system.
Compound Profile
GHRP-6 (Growth Hormone Releasing Hexapeptide-6) is a synthetic hexapeptide and one of the first-generation growth hormone secretagogues, developed to stimulate pituitary GH release via ghrelin receptor (GHS-R1a) agonism. Its sequence — His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ — incorporates D-amino acids at positions 2 and 5 to confer resistance to proteolytic degradation, a common feature of synthetic peptide tool compounds. GHRP-6 is widely used in preclinical research as a reference GHS-R1a agonist for establishing receptor pharmacology baselines. Mechanistically, GHRP-6 acts at the ghrelin receptor (GHS-R1a) to stimulate GH release from anterior pituitary somatotrophs in a pulse-like pattern. Research has examined its effects on GH secretion amplitude, IGF-1 downstream signaling, and interactions with endogenous GHRH (growth hormone-releasing hormone). A notable characteristic of GHRP-6 compared to later GHRPs is its relatively strong ghrelin mimicry — producing appetite stimulation in addition to GH secretion, which has made it a research tool for studying orexigenic signaling alongside GH axis pharmacology. Peptides of China supplies GHRP-6 as a lyophilized powder in sealed vials at 99%+ purity, verified by HPLC and Mass Spectrometry. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. All products are intended for laboratory research use only and are not for human consumption.
Profile
Research Areas
GH axis pharmacology, ghrelin receptor agonism, appetite signaling, pituitary function
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| GHRP-6 | 5 mg | 10 vials | ≥98% | In Stock |
| GHRP-6 | 10 mg | 10 vials | ≥98% | Out of Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS ([“LC-MS”,“HPLC”,“Water Content”]) . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Available documentation: .
**Where provided, these documents reflect the manufacturer’s batch testing for this compound.
Research Areas
GH Secretagogue and Pituitary Research GHRP-6 is a reference compound in GH axis research, reliably stimulating pulsatile GH release in rodent models via GHS-R1a in anterior pituitary somatotrophs. Studies have examined GH pulse amplitude, duration, and frequency following GHRP-6 administration, as well as synergistic interactions with GHRH analogues (such as CJC-1295). It is commonly used as a pharmacological tool to distinguish GHS-R1a-mediated GH release from GHRH-receptor-mediated mechanisms. Ghrelin Receptor Pharmacology As a high-potency GHS-R1a agonist, GHRP-6 is used to study ghrelin receptor biology including signal transduction, receptor desensitization, and downstream Gq/11 and β-arrestin pathway engagement. Its structural characteristics — particularly D-amino acid substitutions — make it a useful probe for identifying receptor binding requirements and designing improved GHS-R1a ligands. Orexigenic Signaling Research GHRP-6 produces measurable appetite-stimulating effects in preclinical models, mimicking one of ghrelin’s primary biological roles. Research has examined hypothalamic NPY/AgRP pathway activation following GHS-R1a engagement, providing a pharmacological tool for studying the intersection of GH secretion and energy intake regulation — two functions co-regulated by the endogenous ghrelin system.