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Ipamorelin

Ipamorelin — research peptide from China

Compound Profile

Chemical Class
Growth Hormone Releasing Peptide (GHRP)
Synonyms
NNC 26-0161
Sequence
Aib-His-D-2Nal-D-Phe-Lys-NH₂ (5 amino acids)
Receptor Target
GHSR-1a (Ghrelin receptor)
Half-Life
~2 h (rodent, i.v.)
Molecular Formula
C₃₈H₄₉N₉O₅
Molecular Weight
711.85 Da
CAS Number
170851-70-4
Storage
-20°C lyophilized; 4°C reconstituted (up to 14 days)
Category
Muscle & Performance, Hormonal Regulation
Total variants
4
In-stock variants
4 of 4
Purity
≥98%
Standard pack size
10 vials

Ipamorelin GH secretagogue research peptide sourced from verified Chinese manufacturer. 5mg & 10mg available. HPLC-verified, purity tested per batch.

Ipamorelin is the gentlest of the growth-hormone secretagogue family, and one of the most reliably stocked chinese peptides across manufacturer catalogs. Its stability in lyophilized form makes it a sensible first order for buyers new to china peptide sourcing, and its popularity makes it a common target for substitution with cheaper GHRPs. We confirm the specific compound and specification with the manufacturer before the order ships.

Buy Ipamorelin Peptide | Growth Hormone Secretagogue | Research Grade | Peptides of China Ipamorelin Buy Ipamorelin — Research Grade GH Secretagogue Ipamorelin is a muscle & performance research compound currently in stock directly from a verified Chinese manufacturer. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. Sourcing is direct — no intermediaries. Public catalog minimum is $300 in goods per supplier. Eligible new customers may use one first-order trial without a monetary minimum; 5% off goods applies from $3,500 per supplier, excluding shipping. International shipping available.

Compound Profile

Ipamorelin is a synthetic pentapeptide (five amino acids) that acts as a selective agonist at the ghrelin receptor (GHSR-1a), classified as a growth hormone releasing peptide (GHRP). Its sequence — Aib-His-D-2-Nal-D-Phe-Lys-NH₂ — includes non-natural amino acid substitutions (Aib at position 1, D-2-naphthylalanine at position 3) that confer receptor selectivity and resistance to peptidase degradation relative to earlier GHRPs such as GHRP-6 and GHRP-2. The key pharmacological distinction is ipamorelin’s minimal effect on cortisol and prolactin — a selectivity profile established in rat pituitary cell studies and confirmed in human volunteer pharmacodynamic trials. Preclinical research characterises ipamorelin primarily through its stimulation of pulsatile growth hormone release from anterior pituitary somatotrophs via GHSR-1a activation and secondary GH-releasing hormone (GHRH) synergism. When co-administered with a GHRH analogue (most commonly CJC-1295 without DAC), GH pulse amplitude is substantially amplified through complementary receptor pathways — making the Ipamorelin + CJC-1295 combination one of the most studied GH secretagogue pairings in both rodent and primate models. IGF-1 elevation downstream of GH release is monitored as a secondary endpoint in most preclinical growth models. Peptides of China supplies research-grade ipamorelin as lyophilized powder in sealed vials at ≥98% purity, verified by HPLC and mass spectrometry. Batch Certificates of Analysis are available. Wholesale orders are accommodated on request. This compound is for laboratory research use only.

Profile

Available Variants

Name Strength Pack Size Purity Availability
Ipamorelin 5 mg 10 vials ≥98% In Stock
Ipamorelin 5 mg 10 vials — In Stock
Ipamorelin 10 mg 10 vials ≥98% In Stock
Ipamorelin 10 mg 10 vials — In Stock

Specification Highlights

Quality & Testing

Testing method: HPLC / LC-MS . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control, using methods such as HPLC and LC-MS. These results are kept in the manufacturer’s internal quality-control records and are not issued as a separate certificate or document.

Research Areas

GH Pulse Physiology & Secretagogue Research Ipamorelin’s GHSR-1a selectivity makes it a useful pharmacological tool for investigating somatotroph function and pulsatile GH secretion. In primary rat pituitary cell cultures, ipamorelin induces concentration-dependent GH release without significant co-stimulation of ACTH, cortisol, or prolactin — a specificity profile useful for isolating GH-axis effects in mechanistic studies. Combined administration with GHRH analogues (particularly CJC-1295 without DAC) produces synergistic GH release, as the two compounds act via independent receptor pathways (GHSR-1a vs. GHRHR). Body Composition & Lean Mass Models Rodent studies using GH-deficient models (hypophysectomised rats, dwarf rats) demonstrate that ipamorelin administration partially restores lean body mass, bone mineral density, and linear growth at doses that do not suppress endogenous GH axis feedback as severely as exogenous GH. The selectivity for somatotrophs over corticotrophs is particularly relevant when modelling the long-term effects of GH axis stimulation in metabolic phenotyping studies. Gastrointestinal Motility Research Ghrelin receptors (GHSR-1a) are expressed throughout the enteric nervous system and GI smooth muscle. Preclinical studies document that GHSR-1a agonists including ipamorelin accelerate gastric emptying in rodent models of post-operative and diabetic gastroparesis. Ipamorelin’s clean cortisol profile makes it a preferred tool compound versus GHRP-6 (which has significant ghrelin/orexigenic activity and cortisol effects) in GI motility mechanistic studies. Bone Density & Connective Tissue Models GH and IGF-1 are established anabolic regulators of bone matrix deposition and periosteal expansion. Ipamorelin-induced GH secretion in ovariectomised rat models of oestrogen deficiency-associated bone loss has been studied in the context of GH axis reactivation strategies. Elevated IGF-1 downstream of GH release stimulates osteoblast differentiation and collagen synthesis in in vitro calvarial osteoblast assays. ## Sourcing Ipamorelin From China

Ipamorelin is available through our platform as a china peptide sourced directly from an established Chinese manufacturer. Three points define how we handle it:

  • Factory-direct, not trader-sourced. We confirm availability and specification with the manufacturer before the order is confirmed. There is no intermediary resale of unknown-origin vials in this catalog.
  • Specification before shipment. The purity and concentration specification shown on this page is the manufacturer’s batch specification. Product-specific quality-control information travels with the order.
  • Research-use discipline. Like every listing in our catalog, Ipamorelin is supplied for laboratory research use only, under strict research-use terms.

For buyers comparing chinese peptides suppliers, the practical test is whether the seller can name the manufacturer and show the batch documentation. We work the other way around: the manufacturer and the documentation are the offer. Browse the full catalog or see how sourcing works.

Frequently Asked Questions

What is the difference between ipamorelin and GHRP-6?

Both are GHSR-1a agonists but differ substantially in selectivity. GHRP-6 also stimulates ghrelin-associated appetite signalling and produces significant cortisol and prolactin elevation in preclinical models. Ipamorelin is selective for pituitary somatotrophs with minimal cortisol, prolactin, or appetite-hormone cross-reactivity — making it the preferred tool compound when researchers wish to isolate GH-axis effects without confounding neuroendocrine activity. Why is ipamorelin often combined with CJC-1295 without DAC in research? Ipamorelin (GHSR-1a agonist) and CJC-1295 without DAC (GHRH receptor agonist) stimulate GH release via distinct receptors. When combined, the two pathways act synergistically — producing GH pulse amplitudes substantially greater than either compound alone. This combination is widely used in preclinical GH secretagogue studies to maximise GH output while minimising dose of either individual agent.

What is the recommended storage for ipamorelin lyophilized powder?

Store lyophilized ipamorelin at -20°C, protected from moisture and UV light. Reconstituted solutions in bacteriostatic water are stable at 4°C for up to 14 days. For longer-term storage of reconstituted peptide, aliquot and store at -80°C, avoiding repeated freeze-thaw cycles.

Is ipamorelin available for wholesale in multi-vial formats?

Yes. Peptides of China supplies ipamorelin in wholesale quantities with tiered pricing. Standard vial sizes and pricing are available on request after account verification. Contact us via the request form.

Research use only. This product is a research compound intended for laboratory research purposes. It is not for human or veterinary use, and is not a medicine, dietary supplement, or cosmetic.

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